Secure online access to Cleveland Clinic's specialists for over 1,200 medical diagnoses, nutritional consultation and pre-adoption advice

Cleveland Clinic News  The latest from our experts

Study: High-Dose Vitamin D Does Not Prevent Heart Disease

Vitamin D SupplementsVitamin D is well-known for its role in prevention and treatment of bone health issues. A new study looks at whether taking a high-dose vitamin D supplement could help prevent heart disease as well. The result: Taking monthly high-doses of vitamin D supplements does nothing to prevent cardiovascular disease.

The researchers tracked the cardiovascular health of about 5,000 adults between ages 50 and 84. About one-quarter were vitamin D deficient at the start of the study.

Half of the participants were assigned to receive a high-dose vitamin D supplement once a month. They first took a dose of 200,000 IUs, then took a regular monthly dose of 100,000 IUs.

The other half of the participants received a monthly regimen of placebos. All participants followed this regimen for more than three years, on average.

The results showed nearly 12 percent of both groups developed some form of cardiovascular disease. The risk for developing high blood pressure and/or experiencing heart attack, stroke, heart failure, or angina was similar whether or not a participant had begun the study with a vitamin D deficiency.

Dietary supplements and heart health